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The demonstration of cardiorenal benefits with SGLT2i in clinical trials both for participants with CKD and type 2 diabetes and for those without [23,24,25] and the updated 2022 KDIGO guidelines recommending SGLT2i as first-line therapy for patients with CKD and type 2 diabetes regardless of glycemic control [6] have likely driven a shift toward their broader use for preventive cardiorenal protection and earlier implementation for patients with type 2 diabetes

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Ritzel R, rskov C, Holst JJ, Nauck MA

A sedentary 50-year-old GLP-1 user requires different amounts than an active 35-year-old engaging in resistance training

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